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In the SURPASS-2 diabetes trial, an open-label 40-week study randomised 1,879 patients with type 2 diabetes to tirzepatide 5, 10, or 15 mg or to semaglutide 1 mg

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[17] [16] Importantly, patients without baseline retinopathy did not demonstrate increased risk, and the overall cardiovascular benefits of semaglutide were maintained despite this ocular safety signal